Sometimes when I launch the game, it won't completely open properly. The in-game sounds will be playing but I'll still be on the desktop. However I can't interact with anything on the screen with my mouse. Pressing Alt-F4 does nothing. I am able to open the task manager with the keyboard but unable to select anything on it with the mouse. However I can select basically anything in Windows with the keyboard. As if they mouse has become locked to in-game. I am unable to force quit the game however in the task manager even with the keyboard. The only thing I can do is ctrl+alt+del, tab to the power button and reset. Basically my entire computer becomes inoperable until I reboot it. I've never had this issue in the past.
Do a barrel roll