This didn't bother me so much for a long while, but now that I'm nearing having all of the home instance nodes (just the treasure chest left to finish) I have to wonder what the person who laid them out was thinking? The home instances are in serious need of some home organization for all of our sanity.
The only home instance that is sort of decently organized is The Grove, but even then you have the Primordial Orchid node off there by itself and the random bandit chest spawn on the roof (!), as well as the wintersday tree up there on the opposite side. Divinity's Reach is a hot mess - you can see a few areas that sort of make aesthetic sense but then stuff is just placed randomly in corners, behind npcs, back in the alleys, all over. I rarely have reason to bother with the other ones, but I've tested them and they basically have the same issue - too much hide-and-seek to gather everything. It's especially a problem if you need to do any glyph swapping (e.g. Industry), since you ideally want to minimize the number of swaps and have all the same type of nodes together.
Even without that, what is the point of making an already-tedious daily chore even worse by randomizing locations of some things and spreading them out so that you have to spend a lot of time running around and swapping? Just line them up in organized and convenient clumps so we can get them gathered and move on quickly. It's not like it would ruin the aesthetics - most of the layouts don't make any sense as it is.