So, like many, many other people on here, I was having lots of issues since the Wintersday patch. I won't go into the details, but eventually I scraped together a full reinstall, adjusted some other settings, and got it to where i don't seem to be crashing upon pulling up a loading screen (fingers crossed) when I run the game as Administrator in WIndows 10.
However, I noticed something odd I had not expected: when running under Administrator: my Mouse 4 (forward) and Mouse 5 (back) buttons are not being recognized by GW2. Mouse 3 still works fine, and I can still see in my custom keybinding for them both m4 nd m5 are still showing them as valid choices that I had set them to previously under Options for the game, but GW2 doesn't seem to be recognizing them anymore as valid keypresses/mouseclicks anymore.
On a hunch, I tried playing the game withough running as Adminsitrator, and they are recognziing those two mouse buttons just fine again (but I dare not run without being Administrator, lest it start crashing on me again).
So, any ideas why it is ignoring those two mouse buttons when running as Adminstrator? I use them quite a lot in-game, and while GW2 is swiftly approaching the 'too many problems to bother playing anymore,' it's not quite there yet.