Same error code 42:0:9001:4457:101 problem with me, the game is really unplayable. Can't even access Black Lion. Anet lost its sales! I've done almost all troubleshooting I could think of. Anet Support suggested to remove Malwarebytes. I've done more like running GW2 only and had game exceptions for firewall/anti-malware, disabling/exiting web anti-virus apps, full uninstallation using ESET for Malwarebytes or any security, turn-off real-time protection of windows defender, allow an app thru-firewall, even turning-off & disabling firewall completely. Sadly, nothing works. Guess what? it has gotten worse now. I can't really play... I had no issues with other multiplayer games & my latency is normal. This network issue happens randomly.