The fact is, that with the current configuration of Lutris, the game runs quite well (not ideal - about ~55-60fps in core Tyria, and between ~25-40 fps in HoT, PoF and other maps, but this is most likely due to old hardware, a have AMD FX-8320 Eight-Core @ 8x 3.5GHz and NVIDIA GeForce GT 740, so... yeah 🙂
Wine - Lutris-GE-Proton8-14
DXVK - 1.10.3
I also tried other configurations of wine and dxvk, but either there were no noticeable improvements, or (what happened more often) an error appeared when starting the client