I have similar problems.
Running GW2 in windowed mode on one of my two monitors.
After some time FPS drops (<10) and the secondary monitor gets disconnected while the main monitor restarts.
Sometimes GW2 even crashes to desktop.
Bringing GW2 to fullscreen restores FPS, but problem with secondary monitor stays.
Strange: When leaving the window by clicking on Desktop or another Window the FPS goes back up until I click into GW2 Window again.
I haven't played for a while so this started for me with the update for end of Dragons.
@Ashantara.8731 Thanks for the Link. I tried it, but it did not help.
I already installed All Windows updates and updated my NVidia Drivers. Also Graphics Card and CPU are far from being fully utilized.