I think your spouse can probably make any of the classes work. Maybe not great, but certainly enough to get by. My mom, who has at least one character of each class, is in the same boat. She's 92 and her left hand is useless due to a very bad tremor. All of Mom's characters are level 80 and she successfully solo'd all of them through map completion to get their Gifts of Exploration. That was doing it all herself, no waypoint purchases, no paying for runs... just her playing by herself. She said she died a lot and had to continually repair her armor, but she did it. She, like your spouse, plays using a mouse to click on skills. She has no fancy mouse or apps -- just the standard keyboard and mouse. Mom is strictly a PvE player and does no PvP, nor WvW, nor does she do fractals, raids nor dungeons and only parties up with our immediate family. Mostly that's because she can't type (chatting in game is out) and she is hard of hearing so she can't do discord. Still, Mom plays every day and makes all of the classes work for her. Her favorite class has varied. Her first favorite class was the ranger with a longbow because the pet tanked and the character could stand way back with the longbow. I also heard her say she liked her guardian and her revenant. (Maybe because they are heavy armor?) The key for Mom seemed to be sticking with a class long enough to get very familiar with the possibilities and setting it up so that once combat was entered, all she had to do was click on the skills with the mouse. She doesn't dodge or move around much, since she has to choose between that and hitting skills, but she still manages to get out of red circles enough of the time to survive. She has preferred more defensive gear to help compensate for having to choose between dodging and attacking. HoT, PoF and most of the Living World maps have been much harder for her. She has continued to explore with her various characters and classes, but has not been able to map complete consistently. Right now she is focussing on crafting Ascended equipment, hoping that will make it more fun for her. I'll check with her and see if I can add some details to this -- more about which classes are the easiest for her to play and how she has them set up. Particularly, which have been the best for her in the harder areas like HoT and the desert.