PlayOnMac seems to have issues downloading Wine packages, so scripts will fail unless you somehow have the correct Wine package already installed. Porting Kit is based on Wineskin, so I perfer to use the latter, I find it easier to tinker with. The original version by doh123 is no longer available; Gcenx is continuing the project, and managed to make it work on Catalina, Big Sur and Silicon. I built a wrapper with Wineskin-2.9.0.7-rc4 and WS11WineCX64Bit20.0.0, but I’m on Mojave so I have no way to test if it works on Silicon. Since I’m not a developer I can’t sign the app, so it may give you a “Guild Wars 2.app is damaged and can’t be opened” error. In that case the Terminal command “xattr -c /path/to/Guild\ Wars\ 2.app” should fix it. To modify it, you can right-click on the wrapper, select “Show Package Content” and launch the Wineskin app inside it. There’s a setting to map Option to Alt, I’m not sure if it should be selected or not.