Well I thought it was related to the latest update to GW2 but I will have to review what packages have been upgraded in the last week. Running PopOS 21.10. The first time I launched the game today, the launcher appeared, downloaded the latest update, and then froze. Killed the processes and tried again. Now GW2 launcher only partially displays and GNOME locks up. Have to jump into TTY to kill processes. I did recently upgrade my graphics card from an R9 270 to an RX580 but I have played GW since then and didn't have to change any configurations.
Not really sure what to check, although I'm now wondering whether I installed the Legacy package because of the 270...