From the DXVK issue mentioned earlier. But since you guys tried several combinations there must be something else causing this behavior.
https://github.com/doitsujin/dxvk/issues/2729
For me wine-ge 7.21 works with freshly compiled DXVK master as well as v1.10.2. BLTC works fine, just sold something.
Edit: Nvidia GTX 1060, Driver 515.57