For what it's worth, with Wine-Staging 7.13 I'm able to play the game in DX11 mode, without DXVK. There is some performance hit, and my CPU runs on a higher load, but it's absolutely playable.
Some quick system info: Arch Linux, Ryzen 3700X, Radeon RX 5700, Linux 5.18.2, Mesa 22.1.3, Wine-Staging 7.13
With DXVK I'm seeing the following crash: