My own personal wish for accessibility is a difficulty slider for the story and dungeons since it's nearly impossible to form groups for older content. Before anyone decides that I must be ignorant in some way on game mechanics, just don't. I've been playing for about 8 years, have several full builds, understand defiance bars, know what a combo skill is, how to dodge AoE, am capable of changing my settings and actually enjoy that GW2 is a complicated and challenging game.
But I have a chronic illness that on top of the visual and aural sensitivities makes me tired and weak, this leads to me being unable to keep up with other active players. It takes me a lot longer to learn fight mechanics because I have to take a lot of breaks which makes it hard to keep groups together. My illness has made me a recluse irl and I spend most of my online gaming without making lasting friendships. I'm not saying this for pity invites, it is just the way life ends up for some people and am already in an awesome guild.
For me HoT and LWS3 are the most engaging and re-playable maps since events are on short reliable timers and only require in-game chat for coordination, not to mention the rewards continue be lucrative. Due to this EoD is a bit of a disappointment for me, mostly because I didn't have a problem with how GW2 kept the casualness of open world and the rigidness of instanced content separate with the earlier releases.
Although I am tentatively excited about the upcoming changes to WvW which is a game mode I really enjoy but it needs updating.
I haven't seen as much discussion in the community about accessibility in a while and it would be wonderful if the developers to notice and actually implement changes. But considering they never have in the past I won't hold my breath.