I don't know what was in that last patch on Nov 8 2021, but since then the game refuses to launch, gets hung, locks up my mouse. I don't have 30 chars, I wasn't using dx11 beta option, and I have zero mods. I tried a "-repair" to no affect. I have been running GW2 on Windows 10 since about Jan/Feb of 2020 with no issues, even running at 4K. I had to add a "-dx11" to end of my launch command to even get the game to boot up and let me log in. Ugh, but at least worked, and seems stable enough (I hope).
Update for Nov 10, 2021 -- the "-dx11" is stable for me, so I guess this is what I'll be doing until the next patch breaks something. I'm using an EVGA 2080TI Hybrid with the latest drivers, if that matters.