imo, if you're just starting the game altogether, you'll want to focus on: Greatsword. A powerful and reliable ranged weapon for open-world and story mode content where enemies die fast and it's often your first time seeing any particular boss' mechanics and animations.Sword/X (Sword/Sword or Sword/Focus). To learn the mechanics of melee fighting with a lightly-armored class: moving to avoid basic attacks, Blurred Frenzy evasion frames, dodging the big stuff. Note that your #1 skill is a three-hit chain so your DPS goes up considerably if you don't constantly interrupt it. I suggest Sword or Focus for your off hand since both give you some extra damage from their phantasms when you need it.Both these weapon sets rely on Power for their damage, so prioritize that on your gear. (Later on you will want Precision and Ferocity as well, to make big consistent critical hits happen. Some amount of Toughness or Vitality is ok as well while you're learning the ropes, just be mindful that trying to play slow-and-steady can actually be harder than mopping up enemies quickly in this game.) Mesmers generally want all the offense they can get because the class is built to use a lot of active defense but doesn't have the biggest raw damage numbers. Power also straightforwardly boosts your Mind Wrack (F1 shatter) damage, so you can start getting used to shattering your clones to kill enemies faster. Eventually, you'll also get a lot of value out of shattering clones using Diversion (F3 shatter) to break through Defiance (the little blue bar) on bosses as well. For Utility skills, experiment a lot, but you'll probably be happiest with: At least one stun break (e.g. Blink or Mirror Images)A condition cleanse skill (i think Power Cleanse is the easiest to use)These will help you when you've been stunned, knocked down, chilled, immobilized, &c.With this setup, the Dueling and Domination trait lines will help you get your damage up quickly. ~ N.B. during leveling, gear is cheap (and often shoddy enough that it doesn't really matter as much), and enemies are relatively easy, so you have room to experiment and dabble. It's much better to reach level 80 having at least tried all the weapons for a few minutes than to not know half of the options available to your class.